Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men

Alcohol consumption is associated with hyperuricemia and gout. Previous studies have indicated a role for green tea catechins in uric acid (UA) metabolism. This study aimed to elucidate the acute effect of terms enhancing urinary excretion UA xanthine/hypoxanthine (Xa/HX; precursors) after alcohol ingestion. In randomized crossover study, ten healthy Japanese subjects consumed test meals, including distilled spirit (Sh?ch?) water (SW) or Sh?ch? catechin-rich (SC), each containing 20 g alcohol. The SC contained 617 mg catechin total. Serum urine Xa/HX concentrations were measured. Blood samples collected 2.5 h, between 0 5 h consuming meal. Urine excretions significantly higher group than SW (UA: SW, 0.45 ± 0.08; SC, 0.52 0.09; Xa/HX: 0.08 0.04; 0.16 0.05 mg/kg/h). clearance (CUA) fractional (FEUA) tended increase more (CUA: 7.76 2.14; 8.75 2.23 mL/min/1.73 m2; FEUA: 6.08 1.36; 6.64 1.42%). No significant differences serum observed two groups. It was concluded that can enhance Xa/HX, even though ingested. UMIN000040076. Retrospectively registered 7 April 2020. https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000045687